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Stateful serverless workflows consist of multiple serverless functions that access state on a remote database. Developers sometimes add a cache layer between the serverless runtime and the database to improve I/O latency. However, in a serverless environment, functions in the same workflow may be scheduled to different nodes with different caches, which can cause non-intuitive anomalies. This paper presents CausalMesh, a novel approach to causally consistent caching in serverless computing. CausalMesh is the first cache system that supports coordination-free and abort-free read/write operations and read transactions when clients roam among multiple servers. CausalMesh also supports read-write transactional causal consistency in the presence of client roaming but at the cost of abort-freedom. Our evaluation shows that CausalMesh has lower latency and higher throughput than existing proposals. 

Abstract ObjectivesTo quantify differences between (1) stratifying patients by predicted disease onset risk alone and (2) stratifying by predicted disease onset risk and severity of downstream outcomes. We perform a case study of predicting sepsis. Materials and MethodsWe performed a retrospective analysis using observational data from Michigan Medicine at the University of Michigan (U-M) between 2016 and 2020 and the Beth Israel Deaconess Medical Center (BIDMC) between 2008 and 2012. We measured the correlation between the estimated sepsis risk and the estimated effect of sepsis on mortality using Spearman’s correlation. We compared patients stratified by sepsis risk with patients stratified by sepsis risk and effect of sepsis on mortality. ResultsThe U-M and BIDMC cohorts included 7282 and 5942 ICU visits; 7.9% and 8.1% developed sepsis, respectively. Among visits with sepsis, 21.9% and 26.3% experienced mortality at U-M and BIDMC. The effect of sepsis on mortality was weakly correlated with sepsis risk (U-M: 0.35 [95% CI: 0.33-0.37], BIDMC: 0.31 [95% CI: 0.28-0.34]). High-risk patients identified by both stratification approaches overlapped by 66.8% and 52.8% at U-M and BIDMC, respectively. Accounting for risk of mortality identified an older population (U-M: age = 66.0 [interquartile range—IQR: 55.0-74.0] vs age = 63.0 [IQR: 51.0-72.0], BIDMC: age = 74.0 [IQR: 61.0-83.0] vs age = 68.0 [IQR: 59.0-78.0]). DiscussionPredictive models that guide selective interventions ignore the effect of disease on downstream outcomes. Reformulating patient stratification to account for the estimated effect of disease on downstream outcomes identifies a different population compared to stratification on disease risk alone. ConclusionModels that predict the risk of disease and ignore the effects of disease on downstream outcomes could be suboptimal for stratification. 

Stateful serverless workflows consist of multiple serverless functions that access state on a remote database. Developers sometimes add a cache layer between the serverless runtime and the database to improve I/O latency. However, in a serverless environment, functions in the same workflow may be scheduled to different nodes with different caches, which can cause non-intuitive anomalies. This paper presents CausalMesh, a novel approach to causally consistent caching in serverless computing. CausalMesh is the first cache system that supports coordination-free and abort-free read/write operations and read transactions when clients roam among multiple servers. CausalMesh also supports read-write transactional causal consistency in the presence of client roaming, but at the cost of abort-freedom. Our evaluation shows that CausalMesh has lower latency and higher throughput than existing proposals. 

Stateful serverless workflows consist of multiple serverless functions that access state on a remote database. Developers sometimes add a cache layer between the serverless runtime and the database to improve I/O latency. However, in a serverless environment, functions in the same workflow may be scheduled to different nodes with different caches, which can cause non-intuitive anomalies. This paper presents CausalMesh, a novel approach to causally consistent caching in serverless computing. CausalMesh is the first cache system that supports coordination-free and abort-free read-/write operations and read transactions when clients roam among multiple servers. CausalMesh also supports read-write transactional causal consistency in the presence of client roaming, but at the cost of abort-freedom. Our evaluation shows that CausalMesh has lower latency and higher throughput than existing proposals. 

Abstract Spin defects in van der Waals materials offer a promising platform for advancing quantum technologies. Here, we propose and demonstrate a powerful technique based on isotope engineering of host materials to significantly enhance the coherence properties of embedded spin defects. Focusing on the recently-discovered negatively charged boron vacancy center ($${{{{{{{{\rm{V}}}}}}}}}_{{{{{{{{\rm{B}}}}}}}}}^{-}$$ $V_B^{-}$) in hexagonal boron nitride (hBN), we grow isotopically purified h¹⁰B¹⁵N crystals. Compared to$${{{{{{{{\rm{V}}}}}}}}}_{{{{{{{{\rm{B}}}}}}}}}^{-}$$ $V_B^{-}$in hBN with the natural distribution of isotopes, we observe substantially narrower and less crowded$${{{{{{{{\rm{V}}}}}}}}}_{{{{{{{{\rm{B}}}}}}}}}^{-}$$ $V_B^{-}$spin transitions as well as extended coherence timeT₂and relaxation timeT₁. For quantum sensing,$${{{{{{{{\rm{V}}}}}}}}}_{{{{{{{{\rm{B}}}}}}}}}^{-}$$ $V_B^{-}$centers in our h¹⁰B¹⁵N samples exhibit a factor of 4 (2) enhancement in DC (AC) magnetic field sensitivity. For additional quantum resources, the individual addressability of the$${{{{{{{{\rm{V}}}}}}}}}_{{{{{{{{\rm{B}}}}}}}}}^{-}$$ $V_B^{-}$hyperfine levels enables the dynamical polarization and coherent control of the three nearest-neighbor¹⁵N nuclear spins. Our results demonstrate the power of isotope engineering for enhancing the properties of quantum spin defects in hBN, and can be readily extended to improving spin qubits in a broad family of van der Waals materials.